Franck Bonnetain is a full Professor in epidemiology and biostatistics who received a master’s degree in clinical epidemiology from School of Public Health (Nancy, France). He obtained a PhD in public health with epidemiology and statistics specialties in 2005 as well asthe “Habilitation à diriger des recherches” (Professoral capability) in 2010. 



After working as epidemiologist for 3 years in Dijon for the “Institut de Veille Sanitaire”, he served as epidemiologist and biostatistician for the design, analyses and interpretation of clinical trials in Oncology. He was head of the methodology unit of French Federation of Digestive Cancerology (FFCD) and as head of methodology and quality of life unit of Georges François Leclerc Cancer care center from 2003 to 2012 (Dijon, France). Finally in September 2012 he was nominated as Professor in biostatistics, epidemiology, public health and quality of life in oncology at the university hospital of Besançon. He took the head of the methodology and quality of life in oncology unit.

In 2009, he launched and was co-founder of the French national clinical research plateform “Quality of life and cancer”.

He teaches statistics, epidemiology, methodology of clinical trials and quality of life in medical and pharmaceutical school as well as for master degree.


Research thematic:

Definition, selection and validation of endpoints used in oncology clinical trials

Health related quality of life and other Patient reported outcome in oncology

Design of clinical trials and epidemiological studies in oncology

Development of prognostic and predictive scoring system


Main areas of expertise:

- Methodology Statistics and clinical epidemiology

- Clinical trial and clinical research

- Quality of life

- Patient reported outcome

- Oncology

- Digestive Oncology

- Consensus methodology

- Supportive care


Main ongoing external collaborations:

- Full Member of EORTC QoL group since 2010 and board of Probe project since 2014

- Member of ARCAD Clinical Trials Program (http://arcad.marcelww.com/nos-actions/programmes-de-recherche/arcad-clinical-trials-program) and co-head of pancreatic cancer meta-analysis

- Head of DATECAN initiative (internal consensus for the definition of composite endpoints used in oncology clinical trials)

- Head of methodology of GERCOR since 2009 and member of PRODIGE group - Secretary of the AFSOS-UNICANCER French national supportive care group since 2013

- Referent Methodologist expert for GERICO (Geriatric oncology trials in France) and GI group of Unicancer

- Board of ANOCEF since 2010 (Association des neuro-oncologues d’expression française)

- Member of Cochrane lung cancer


Tools online

- Prognostic Score and Nomogram to Predict Overall Survival in Locally Advanced Pancreatic Cancer: The PROLAP score (mettre un lien qui renvoit sur l’outil)

Principaux articles

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AbstractBACKGROUND:The combination of an anti-VEGF or an anti-EGFR-targeted monoclonal antibody with chemotherapy has...

Posté par : Pr. Franck BONNETAIN, Dr. Dewi VERNEREY
Nom de la revue : Lancet Oncol

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AbstractPURPOSE:The MOSAIC (Multicenter International Study of Oxaliplatin/Fluorouracil/Leucovorin in the Adjuvant...

Posté par : Dr. Dewi VERNEREY, Pr. Franck BONNETAIN
Nom de la revue : JCO

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Background: In advanced pancreatic ductal adenocarcinoma (aPDAC), there is no consensual strategy for...

Posté par : Dr. Dewi VERNEREY, Pr. Franck BONNETAIN, Mme. Aurélia MEURISSE
Nom de la revue : JNCI J Natl Cancer Inst

Derniers articles

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Background: Even though the perioperative chemotherapy improves the overall survival (OS) compared to surgery alone in...

Posté par : Pr. Franck BONNETAIN, , Dr. Sophie PAGET-BAILLY
Nom de la revue : European Journal of Surgical Oncology

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La mesure de la qualité de vie relative à la santé des personnes traitées pour un cancer se développe. Ce nouvel...

Posté par : Pr. Franck BONNETAIN, Dr. Guillaume MOUILLET, Mme. Joëlle FRITZSCH, Dr. Sophie PAGET-BAILLY, Mme. Ikram ES-SAAD
Nom de la revue : La revue de l'infirmière

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ABSTRACTBackground and objective: Health-related quality of life (HRQoL) has become one relevant and...

Posté par : Pr. Franck BONNETAIN, Dr. Amélie ANOTA
Nom de la revue : Computer Methods and Programs in Biomedicine

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AbstractBACKGROUND:We investigated whether the health-related quality of life (HRQoL) score is a prognostic factor for...

Posté par : Pr. Franck BONNETAIN, Dr. Dewi VERNEREY,
Nom de la revue : EJC

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Background: The management of locally advanced pancreatic cancer (LAPC) patients remains controversial. Better...

Posté par : Dr. Dewi VERNEREY, Pr. Franck BONNETAIN
Nom de la revue : British Journal of Cancer

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Since the MOSAIC study, oxaliplatin-based adjuvant chemotherapy has been the standard treatment of stage III colon...

Posté par : Dr. Dewi VERNEREY, Pr. Franck BONNETAIN
Nom de la revue : Annals of Oncology

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BACKGROUND:A randomized multicenter phase II trial was conducted to assess the sequential treatment strategy using...

Posté par : Pr. Franck BONNETAIN, Dr. Sophie PAGET-BAILLY, Dr. Guillaume MOUILLET, Dr. Amélie ANOTA
Nom de la revue : PlosOne

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Our aim was to review the studies which assessed potential surrogate endpoints for overall survival (OS) in breast...

Posté par : , Pr. Franck BONNETAIN
Nom de la revue : Breast

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Background Nab-paclitaxel plus gemcitabine has become a standard treatment regimen in patients with metastatic...

Posté par : Pr. Franck BONNETAIN, Mme. Aurélia MEURISSE
Nom de la revue : Lancet Gastroenterology Hepatology

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ABSTRACTPurpose Reduction of adjuvant treatment duration may decrease toxicities without loss of efficacy in stage III...

Posté par : Dr. Dewi VERNEREY, Dr. Sophie PAGET-BAILLY, Pr. Franck BONNETAIN
Nom de la revue : Journal of Clinical Oncology

Dernières actualités

Derniers outils

The R package QoLR allows to compute the scoring of main EORTC quality of life questionnaires and to perform the...

Posté par : Pr. Franck BONNETAIN, Dr. Amélie ANOTA

The R package QoLR allows to compute the scoring of main EORTC quality of life questionnaires and to perform the...

Posté par : Dr. Amélie ANOTA, Dr. Dewi VERNEREY, Dr. Amélie ANOTA, Pr. Franck BONNETAIN, Dr. Amélie ANOTA

The management of locally advanced pancreatic cancer (LAPC) patients remains controversial. Better discrimination for...

Posté par : Pr. Franck BONNETAIN, Dr. Sophie PAGET-BAILLY, Dr. Dewi VERNEREY

MRQoL is a package that consists of three functions which allows us to calculate the Minimal Clinically Important...

Posté par : Pr. Franck BONNETAIN, Dr. Amélie ANOTA, Mr. Ahmad OUSMEN

The R package QoLR allows to compute the scoring of main EORTC quality of life questionnaires and to perform the...

Posté par : Dr. Amélie ANOTA, Dr. Dewi VERNEREY, Dr. Amélie ANOTA, Pr. Franck BONNETAIN, Dr. Amélie ANOTA

Communication from Pr Bonnetain at the 2nd EORTC Cancer Clinical Research Methodology Course for Patient Advocates,...

Posté par : Pr. Franck BONNETAIN

Posté par : Pr. Franck BONNETAIN, Dr. Dewi VERNEREY

Découvrez la présentation du Pr Bonnetain dans le cadre du séminaire du Cancéropôle Ile de France sur les tumeurs...

Posté par : Dr. Sophie PAGET-BAILLY, Pr. Franck BONNETAIN

Randomized Phase II Study of Weekly ABI-007plus Gemcitabine or Simplified LV5FU2 as FirstlineTherapy in Patients with...

Posté par : Pr. Franck BONNETAIN

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