Franck Bonnetain is a full Professor in epidemiology and biostatistics who received a master’s degree in clinical epidemiology from School of Public Health (Nancy, France). He obtained a PhD in public health with epidemiology and statistics specialties in 2005 as well asthe “Habilitation à diriger des recherches” (Professoral capability) in 2010. 



After working as epidemiologist for 3 years in Dijon for the “Institut de Veille Sanitaire”, he served as epidemiologist and biostatistician for the design, analyses and interpretation of clinical trials in Oncology. He was head of the methodology unit of French Federation of Digestive Cancerology (FFCD) and as head of methodology and quality of life unit of Georges François Leclerc Cancer care center from 2003 to 2012 (Dijon, France). Finally in September 2012 he was nominated as Professor in biostatistics, epidemiology, public health and quality of life in oncology at the university hospital of Besançon. He took the head of the methodology and quality of life in oncology unit.

In 2009, he launched and was co-founder of the French national clinical research plateform “Quality of life and cancer”.

He teaches statistics, epidemiology, methodology of clinical trials and quality of life in medical and pharmaceutical school as well as for master degree.


Research thematic:

 Definition, selection and validation of endpoints used in oncology clinical trials 

Health related quality of life and other Patient reported outcome in oncology

Design of clinical trials and epidemiological studies in oncology

Development of prognostic and predictive scoring system


Main areas of expertise:

- Methodology Statistics and clinical epidemiology

- Clinical trial and clinical research

- Quality of life

- Patient reported outcome

- Oncology

- Digestive Oncology

- Consensus methodology

- Supportive care


Main ongoing external collaborations:


- Full Member of EORTC QoL group since 2010 and board of Probe project since 2014

- Member of ARCAD Clinical Trials Program (http://arcad.marcelww.com/nos-actions/programmes-de-recherche/arcad-clinical-trials-program) and co-head of pancreatic cancer meta-analysis

- Head of DATECAN initiative (internal consensus for the definition of composite endpoints used in oncology clinical trials)

- Head of methodology of GERCOR since 2009 and member of PRODIGE group - Secretary of the AFSOS-UNICANCER French national supportive care group since 2013

- Referent Methodologist expert for GERICO (Geriatric oncology trials in France) and GI group of Unicancer

- Board of ANOCEF since 2010 (Association des neuro-oncologues d’expression française)

- Member of Cochrane lung cancer


Tools online

- Prognostic Score and Nomogram to Predict Overall Survival in Locally Advanced Pancreatic Cancer: The PROLAP score (mettre un lien qui renvoit sur l’outil)

Main publications

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AbstractBACKGROUND:The combination of an anti-VEGF or an anti-EGFR-targeted monoclonal antibody with chemotherapy has...

Posted by : Pr. Franck BONNETAIN, Dr. Dewi VERNEREY
Journal name : Lancet Oncol

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AbstractPURPOSE:The MOSAIC (Multicenter International Study of Oxaliplatin/Fluorouracil/Leucovorin in the Adjuvant...

Posted by : Dr. Dewi VERNEREY, Pr. Franck BONNETAIN
Journal name : JCO

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Background: In advanced pancreatic ductal adenocarcinoma (aPDAC), there is no consensual strategy for second-line...

Posted by : Dr. Dewi VERNEREY, Pr. Franck BONNETAIN, Mme. Aurelia MEURISSE
Journal name : JNCI J Natl Cancer Inst

Latest publications

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Background: Even though the perioperative chemotherapy improves the overall survival (OS) compared to surgery alone in...

Posted by : Pr. Franck BONNETAIN, Dr. Frederic FITENI, Dr. Sophie PAGET-BAILLY
Journal name : European Journal of Surgical Oncology

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The measurement of the quality of life in terms of health of people undergoing treatment for cancer is developing. Th is...

Posted by : Pr. Franck BONNETAIN, Dr. Guillaume MOUILLET, Mme. Joëlle FRITZSCH, Dr. Sophie PAGET-BAILLY, Mme. Ikram ES-SAAD
Journal name : La revue de l'infirmière

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AbstractBACKGROUND:We investigated whether the health-related quality of life (HRQoL) score is a prognostic factor for...

Posted by : Pr. Franck BONNETAIN, Dr. Dewi VERNEREY, Dr. Frederic FITENI
Journal name : EJC

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Background:The management of locally advanced pancreatic cancer (LAPC) patients remains controversial. Better...

Posted by : Dr. Dewi VERNEREY, Pr. Franck BONNETAIN
Journal name : British Journal of Cancer

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Since the MOSAIC study, oxaliplatin-based adjuvant chemotherapy has been the standard treatment of stage III colon...

Posted by : Dr. Dewi VERNEREY, Pr. Franck BONNETAIN
Journal name : Annals of Oncology

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BACKGROUND:A randomized multicenter phase II trial was conducted to assess the sequential treatment strategy using...

Posted by : Pr. Franck BONNETAIN, Dr. Sophie PAGET-BAILLY, Dr. Guillaume MOUILLET, Dr. Amélie ANOTA
Journal name : PlosOne

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Our aim was to review the studies which assessed potential surrogate endpoints for overall survival (OS) in breast...

Posted by : Dr. Frederic FITENI, Pr. Franck BONNETAIN
Journal name : Breast

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Background Nab-paclitaxel plus gemcitabine has become a standard treatment regimen in patients with metastatic...

Posted by : Pr. Franck BONNETAIN, Mme. Aurelia MEURISSE
Journal name : Lancet Gastroenterology Hepatology

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AbstractBackground: Health-related quality of life (HRQoL) is recognized as a component endpoint for cancer...

Posted by : Dr. Frederic FITENI, Dr. Amélie ANOTA, Pr. Franck BONNETAIN
Journal name : BMC Cancer

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Docetaxel, cisplatin, and 5-fluorouracil (DCF) significantly improved overall survival in metastatic gastroesophageal...

Posted by : Pr. Franck BONNETAIN, Dr. Sophie PAGET-BAILLY, Dr. Frederic FITENI
Journal name : Cancer Medecine

Latest News

Latest tools

The R package QoLR allows to compute the scoring of main EORTC quality of life questionnaires and to perform the...

Posted by : Pr. Franck BONNETAIN, Dr. Amélie ANOTA

The R package QoLR allows to compute the scoring of main EORTC quality of life questionnaires and to perform the...

Posted by : Dr. Amélie ANOTA, Dr. Dewi VERNEREY, Dr. Amélie ANOTA, Pr. Franck BONNETAIN, Dr. Amélie ANOTA

The management of locally advanced pancreatic cancer (LAPC) patients remains controversial. Better discrimination for...

Posted by : Pr. Franck BONNETAIN, Dr. Sophie PAGET-BAILLY, Dr. Dewi VERNEREY

MRQoL is a package that consists of three functions which allows us to calculate the Minimal Clinically Important...

Posted by : Pr. Franck BONNETAIN, Dr. Amélie ANOTA, Mr. Ahmad OUSMEN

The R package QoLR allows to compute the scoring of main EORTC quality of life questionnaires and to perform the...

Posted by : Dr. Amélie ANOTA, Dr. Dewi VERNEREY, Dr. Amélie ANOTA, Pr. Franck BONNETAIN, Dr. Amélie ANOTA

Communication from Pr Bonnetain at the 2nd EORTC Cancer Clinical Research Methodology Course for Patient Advocates,...

Posted by : Pr. Franck BONNETAIN

Posted by : Pr. Franck BONNETAIN, Dr. Dewi VERNEREY

Discover Pr Bonnetain's keynote during the canceropôle IDF' seminar on rare tumours.Listen to the keynote here.Discover...

Posted by : Dr. Sophie PAGET-BAILLY, Pr. Franck BONNETAIN

Randomized Phase II Study of Weekly ABI-007plus Gemcitabine or Simplified LV5FU2 as FirstlineTherapy in Patients with...

Posted by : Pr. Franck BONNETAIN

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